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Male bias in health research targeted by scientists

Network led by a St John鈥檚 biologist works to transform understanding of women鈥檚 medical research and care
Professor Amanda Sferruzzi-Perri

How is it possible that a woman is 50 per cent more likely to receive the wrong initial diagnosis for a heart attack than a man? 聽

Or that men who report pain to a doctor tend to be prescribed pain medication, but women are more likely to be given sedatives or antidepressants?

The historically male-dominated medical profession has driven a male bias in health research and care. 聽

Now a new network of experts at the University of Cambridge is trying to redress the balance.

鈥淩esearch that wasn鈥檛 designed with women in mind has contributed to a healthcare system that doesn鈥檛 meet women鈥檚 needs,鈥 said network leader Professor Amanda Sferruzzi-Perri, University Professor in Fetal and Placental Physiology in the Department of Physiology, Development and Neuroscience, and a Fellow of St John鈥檚.

For centuries, many aspects of female biology were not discussed 鈥 and in some cultures this is still the case today. Women have been sidelined or excluded from research into health conditions and drug treatments, their fluctuating hormones thought to be too much of a complication to getting reliable results.

The result is an alarming lack of understanding of many women鈥檚 health conditions, the ways women experience illness and disease differently to men, and the differences in their response to treatments.

Professor Sferruzzi-Perri, who is College Lecturer in Physiology and Reproductive Biology, says the waves of hormonal changes that happen throughout a woman鈥檚 reproductive years, which don鈥檛 occur in men, affect the body鈥檚 immune system, metabolic system, and cardiovascular and respiratory systems.

鈥淧uberty, pregnancy, breastfeeding and menopause can all permanently alter the female body and are associated with a range of female-specific health issues and benefits,鈥 she said. 聽

鈥淭his leads to different rates of certain conditions in men and women, as well as differences in how these conditions are experienced. We can鈥檛 simply generalise medical treatment across the sexes.鈥

Members of the network working to vastly improve understanding of women鈥檚 health are academics across University Departments, including in mental health, breastfeeding, and archaeology.

Read the full feature, , on the University of Cambridge website.

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